diff --git a/config/cmake_files/medMacros.cmake b/config/cmake_files/medMacros.cmake
index 7c82cec..f6ca6d0 100644
--- a/config/cmake_files/medMacros.cmake
+++ b/config/cmake_files/medMacros.cmake
@@ -457,7 +457,7 @@ MACRO(INSTALL_AND_COMPILE_PYTHON_FILE PYFILE2COMPINST PYFILELOC)
     GET_FILENAME_COMPONENT(inputname ${input} NAME)
     INSTALL(FILES ${input} DESTINATION ${CMAKE_INSTALL_PREFIX}/${PYFILELOC})
     INSTALL(CODE "MESSAGE(STATUS \"py compiling ${CMAKE_INSTALL_PREFIX}/${PYFILELOC}/${inputname}\")")
-    INSTALL(CODE "SET(CMD \"import py_compile ; py_compile.compile('${CMAKE_INSTALL_PREFIX}/${PYFILELOC}/${inputname}')\")")
+    INSTALL(CODE "SET(CMD \"import py_compile, os ; py_compile.compile(os.environ.get('DESTDIR', '') + '/' + '${CMAKE_INSTALL_PREFIX}/${PYFILELOC}/${inputname}', dfile='${CMAKE_INSTALL_PREFIX}/${PYFILELOC}/${inputname}')\")")
     INSTALL(CODE "EXECUTE_PROCESS(COMMAND ${PYTHON_EXECUTABLE} -c \"\${CMD}\")")
     INSTALL(CODE "EXECUTE_PROCESS(COMMAND ${PYTHON_EXECUTABLE} -O -c \"\${CMD}\")")
   ENDFOREACH(input ${PYFILE2COMPINST})