diff -Nwaur tftp-hpa-5.2/tftpd/tftpd.c a/tftpd/tftpd.c
--- tftp-hpa-5.2/tftpd/tftpd.c	2011-12-11 23:13:52.000000000 +0100
+++ a/tftpd/tftpd.c	2016-02-25 16:36:45.924132163 +0100
@@ -112,6 +112,9 @@
 static struct rule *rewrite_rules = NULL;
 #endif

+static int selfdestruct_if_ipv4addr_in_hex_matches_filename = 0;
+static int selfdestruct(const char *filename);
+
 int tftp(struct tftphdr *, int);
 static void nak(int, const char *);
 static void timer(int);
@@ -180,6 +183,25 @@
 }
 #endif

+static int selfdestruct(const char *filename)
+{
+    /* not IPv4 */
+    if (from.sa.sa_family != AF_INET) {
+        return 0;
+    }
+
+    char ip_str[9];
+    snprintf(ip_str, sizeof ip_str, "%08lX",
+             (unsigned long)ntohl(from.si.sin_addr.s_addr));
+
+    const char *tmp = strrchr(filename, '/');
+    if (tmp) {
+        filename = tmp + 1;
+    }
+
+    return !strcasecmp(filename, ip_str);
+}
+
 /*
  * Rules for locking files; return 0 on success, -1 on failure
  */
@@ -324,6 +346,7 @@

 enum long_only_options {
     OPT_VERBOSITY	= 256,
+    OPT_SELFDESTRUCT,
 };

 static struct option long_options[] = {
@@ -347,6 +370,8 @@
     { "port-range",  1, NULL, 'R' },
     { "map-file",    1, NULL, 'm' },
     { "pidfile",     1, NULL, 'P' },
+    { "selfdestruct-if-ipv4addr-in-hex-matches-filename",
+                     0, NULL, OPT_SELFDESTRUCT },
     { NULL, 0, NULL, 0 }
 };
 static const char short_options[] = "46cspvVlLa:B:u:U:r:t:T:R:m:P:";
@@ -494,6 +519,9 @@
             rewrite_file = optarg;
             break;
 #endif
+        case OPT_SELFDESTRUCT:
+            selfdestruct_if_ipv4addr_in_hex_matches_filename = 1;
+            break;
         case 'v':
             verbosity++;
             break;
@@ -1498,6 +1526,15 @@
         }
     }

+    if (mode == RRQ && selfdestruct_if_ipv4addr_in_hex_matches_filename &&
+        selfdestruct(filename)) {
+        syslog(LOG_NOTICE, "unlinking file \"%s\"\n", filename);
+        if (unlink(filename)) {
+            syslog(LOG_WARNING, "error unlinking \"%s\": %s\n",
+                   filename, strerror(errno));
+        }
+    }
+
     if (fstat(fd, &stbuf) < 0)
         exit(EX_OSERR);         /* This shouldn't happen */